Retigabine is shown to be active against electrically induced seizures and against chemical seizures induced by pentylenetetrazole, picrotoxin and NMDA in mice. ED50 of Retigabine for them ranges from 4.0 to18.6 mg/kg (i.p.).In the full amygdala-kindling model of complex partial seizures in rats, Retigabine, at 0.01 mg/kg to 5 mg/kg, i.p., has been reported to dose dependently increase the threshold current for induction of after discharges. Following stimulation with the after discharge threshold current, Retigabine (5 mg/kg, i.p.) also reduces other seizure measures including seizure severity, seizure duration, total duration of behavioral changes and of changes after discharge.

June 21, 2017

prudect name : Retigabine is shown to be active against electrically induced seizures and against chemical seizures induced by pentylenetetrazole, picrotoxin and NMDA in mice. ED50 of Retigabine for them ranges from 4.0 to18.6 mg/kg (i.p.).In the full amygdala-kindling model of complex partial seizures in rats, Retigabine, at 0.01 mg/kg to 5 mg/kg, i.p., has been reported to dose dependently increase the threshold current for induction of after discharges. Following stimulation with the after discharge threshold current, Retigabine (5 mg/kg, i.p.) also reduces other seizure measures including seizure severity, seizure duration, total duration of behavioral changes and of changes after discharge.
Retigabine (Ezogabine)

Synonyms: Retigabine (Ezogabine)CAS NO: 150812-12-7Molecular Formula: C₁₆H₁₈FN₃O₂Molecular Weight: 303.3314232Purity: 99%Solubility: In DMSOStorage: −20°C 2 years

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