AC220 (AC 220, AC220) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ¡À 0.3 nM and >10 mM for MC4-11 and A375, respectively. AC220 (AC 220, AC220) exhibits low nanomolar potency in biochemical and cellular assays and exceptional kinase selectivity, and in animal models is efficacious at doses as low as 1 mg/kg given orally once daily. The data reveal that the combination of excellent potency, selectivity, and pharmacokinetic properties is unique to AC220 (AC 220, AC220), which therefore is the first candidate with a profile that matches the characteristics desirable for a clinical FLT3 inhibitor.

June 21, 2017

prudect name : AC220 (AC 220, AC220) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ¡À 0.3 nM and >10 mM for MC4-11 and A375, respectively. AC220 (AC 220, AC220) exhibits low nanomolar potency in biochemical and cellular assays and exceptional kinase selectivity, and in animal models is efficacious at doses as low as 1 mg/kg given orally once daily. The data reveal that the combination of excellent potency, selectivity, and pharmacokinetic properties is unique to AC220 (AC 220, AC220), which therefore is the first candidate with a profile that matches the characteristics desirable for a clinical FLT3 inhibitor.
Quizartinib AC-220

Synonyms: Quizartinib AC-220CAS NO: 950769-58-1Molecular Formula: C₂₉H₃₂N₆O₄SMolecular Weight: 560.67Purity: 98% minSolubility: In DMSOStorage: −20°C

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