Biological Activity of Perifosine: A p.o.-bioavailable ALK(Alkylphospholipids),inhibits Akt activation. Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. Perifosine has a lower gastrointestinal toxicity profile than the related agent miltefosine. Immortalized keratinocytes (HaCaT) as well as head and neck squamous carcinoma cells were sensitive to the antiproliferative properties of perifosine with an IC50 of 0.6¨C8.9 ¦ÌM

June 21, 2017

prudect name : Biological Activity of Perifosine:
A p.o.-bioavailable ALK(Alkylphospholipids),inhibits Akt activation. Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. Perifosine has a lower gastrointestinal toxicity profile than the related agent miltefosine. Immortalized keratinocytes (HaCaT) as well as head and neck squamous carcinoma cells were sensitive to the antiproliferative properties of perifosine with an IC50 of 0.6¨C8.9 ¦ÌM
Perifosine

Synonyms: KRX-0401, NSC 639966CAS NO: 157716-52-4Molecular Formula: C₂₅H₅₂NO₄PMolecular Weight: 461.66Purity: 98% minSolubility: In DMSOStorage: −20°C

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