A novel broad-spectrum HDAC(histone deacetylase) inhibitor belongs to the hydroxamate class, in Philadelphia chromosome¨Cnegative (Ph-) acute lymphoblastic leukemia (ALL). Histone deacetylases (HDACs) are responsible for deacetylating histones and nonhistone proteins, thus regulating gene transcription, protein function, and stability.Aberrant recruitment of HDACs has been shown to play an important role in leukemogenesis, and alterations in the expression and/or activity of HDACs have been also observed in solid tumors.The 50% inhibitory concentration (IC50) value for inhibition of proliferation in MOLT-4 cells is approximately 5 nM and for Reh cells is approximately 20 nM.Similar results were observed at 24 and 72 hours.

June 21, 2017

prudect name : A novel broad-spectrum HDAC(histone deacetylase) inhibitor belongs to the hydroxamate class, in Philadelphia chromosome¨Cnegative (Ph-) acute lymphoblastic leukemia (ALL).
Histone deacetylases (HDACs) are responsible for deacetylating histones and nonhistone proteins, thus regulating gene transcription, protein function, and stability.Aberrant recruitment of HDACs has been shown to play an important role in leukemogenesis, and alterations in the expression and/or activity of HDACs have been also observed in solid tumors.The 50% inhibitory concentration (IC50) value for inhibition of proliferation in MOLT-4 cells is approximately 5 nM and for Reh cells is approximately 20 nM.Similar results were observed at 24 and 72 hours.
Panobinostat

Synonyms: LBH-589 CAS NO: 404950-80-7Molecular Formula: C₂₁H₂₃N₃O₂Molecular Weight: 349.43Purity: 98% minSolubility: In DMSOStorage: −20°C

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