Biological Activity of PLX-4720: PLX4720, a 7-azaindole derivative that inhibits B-RafV600E with an IC50 of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays. PLX4720 preferentially inhibits the active B-RafV600E kinase compared with a broad spectrum of other kinases (IC50:B-Raf=160 nM, BRK=130 nM, other kinases >1000nM), and potent cytotoxic effects are also exclusive to cells bearing the V600E allele (GI50<1.7 ¦ÌM, while other wild cell GI50>10¦ÌM).

June 21, 2017

prudect name : Biological Activity of PLX-4720:
PLX4720, a 7-azaindole derivative that inhibits B-RafV600E with an IC50 of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays. PLX4720 preferentially inhibits the active B-RafV600E kinase compared with a broad spectrum of other kinases (IC50:B-Raf=160 nM, BRK=130 nM, other kinases >1000nM), and potent cytotoxic effects are also exclusive to cells bearing the V600E allele (GI50<1.7 ¦ÌM, while other wild cell GI50>10¦ÌM).
PLX 4720

Synonyms: CAS NO: 918505-84-7Molecular Formula: C₁₇H₁₄ClF₂N₃O₃SMolecular Weight: 413.83Purity: 99%Solubility: In DMSOStorage: −20°C

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