PH-797804 is a highly selective, potent, and ATP-competitive p38 MAP kinase inhibitor with an IC50 of 2.3 nM.PH-797804 reversibly inhibits the alpha isoform of human p38 MAP kinase with a Ki of 5.8 nM.Additionally, in a human peripheral blood monocyte assay, PH-797804 inhibits hPBMC TNF, exhibiting IC50 of 3.4 nM. Indeed, PH-797804 revealed exceptionally high specificity against MAP kinases and the related kinases. In cellular assays, PH-797804 demonstrated superior potency and selectivity in good line with the biochemical measurements.

June 21, 2017

prudect name : PH-797804 is a highly selective, potent, and ATP-competitive p38 MAP kinase inhibitor with an IC50 of 2.3 nM.PH-797804 reversibly inhibits the alpha isoform of human p38 MAP kinase with a Ki of 5.8 nM.Additionally, in a human peripheral blood monocyte assay, PH-797804 inhibits hPBMC TNF, exhibiting IC50 of 3.4 nM. Indeed, PH-797804 revealed exceptionally high specificity against MAP kinases and the related kinases. In cellular assays, PH-797804 demonstrated superior potency and selectivity in good line with the biochemical measurements.
PH 797804

Synonyms: CAS NO: 586379-66-0Molecular Formula: C₂₂H₁₉BrF₂N₂O₃Molecular Weight: 477.30Purity: 98%Solubility: In DMSOStorage: -20°C

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