PHT-427 is a dual Akt and PDPK1 inhibitor that affects downstream targetsamong sensitive but not resistant cells and tumor xenografts. When given orally, PHT-427 inhibited the growth of human tumor xenografts in immunodeficient mice, with up to 80% inhibition in the most sensitive tumors, and showed greater activity than analogues with C4, C6, or C8 alkyl chains. Inhibition of PDPK1 was more closely correlated to antitumor activity than Akt inhibition.

June 21, 2017

prudect name : PHT-427 is a dual Akt and PDPK1 inhibitor that affects downstream targetsamong sensitive but not resistant cells and tumor xenografts. When given orally, PHT-427 inhibited the growth of human tumor xenografts in immunodeficient mice, with up to 80% inhibition in the most sensitive tumors, and showed greater activity than analogues with C4, C6, or C8 alkyl chains. Inhibition of PDPK1 was more closely correlated to antitumor activity than Akt inhibition.
PHT-427

Synonyms: CAS NO: 1191951-57-1Molecular Formula: C₂₀H₃₁N₃O₂S₂Molecular Weight: 409.61Purity: 98% minSolubility: In DMSOStorage: -20°C

web site: www.medchemexpress.com

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18538919