Nelarabine(Arranon) is a chemotherapy drug used in T-cell acute lymphoblastic leukemia. Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity. Pre-clinical studies suggest that T-cells are particularly sensitive to nelarabine. This drug performed growth inhibitory activity (IC50 = 1.61 µM) against MOLT-4 cells

June 21, 2017

prudect name : Nelarabine(Arranon) is a chemotherapy drug used in T-cell acute lymphoblastic leukemia. Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity. Pre-clinical studies suggest that T-cells are particularly sensitive to nelarabine. This drug performed growth inhibitory activity (IC50 = 1.61 µM) against MOLT-4 cells
Nelarabine

Synonyms: ArranonCAS NO: 121032-29-9Molecular Formula: C₁₁H₁₅N₅O₅Molecular Weight: 297.27Purity: 99%Solubility: In DMSOStorage: −20°C 2 years

web site: www.medchemexpress.com

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18536104