NU7441 is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 0.01, 1.7 and 5 ¦ÌM for DNA-PK, mTOR and PI 3-K, respectively. NU7441 has less inhibitory activity against ATM and ATR (IC50 valuse>100 ¦ÌM). NU7441 increased the cytotoxicity of IR and etoposide in V3-YAC cells but not in V3 cells, confirming that DNA-PKcs is the cellular target of NU7441. NU7441 alone had no effect on cell cycle distribution, but accumulation in G2/M induced by exposure to IR (2 Gy) or the topoisomerase II poisons, doxorubicin (10 nM) or etoposide (0.1 µM) was increased 1.2 to 2 fold by NU7441 in SW620 cells.

June 21, 2017

prudect name : NU7441 is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 0.01, 1.7 and 5 ¦ÌM for DNA-PK, mTOR and PI 3-K, respectively. NU7441 has less inhibitory activity against ATM and ATR (IC50 valuse>100 ¦ÌM). NU7441 increased the cytotoxicity of IR and etoposide in V3-YAC cells but not in V3 cells, confirming that DNA-PKcs is the cellular target of NU7441. NU7441 alone had no effect on cell cycle distribution, but accumulation in G2/M induced by exposure to IR (2 Gy) or the topoisomerase II poisons, doxorubicin (10 nM) or etoposide (0.1 µM) was increased 1.2 to 2 fold by NU7441 in SW620 cells.
NU7441

Synonyms: KU 57788CAS NO: 503468-95-9Molecular Formula: C25H19NO3SMolecular Weight: 413.49Purity: 98% minSolubility: In DMSOStorage: −20°C


web site: www.medchemexpress.com

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18537130