Selective inhibitor of TGF-¦Â type-I receptor (TGF-¦Â RI, TGFR-I, T¦ÂR-I, ALK-5) (IC50 values are 59, 400 and 1400 nM for TGR-¦Â RI, TGF-¦Â RII and MLK-7K respectively). Inhibits TGF-¦Â-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89 nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.

June 21, 2017

prudect name : Selective inhibitor of TGF-¦Â type-I receptor (TGF-¦Â RI, TGFR-I, T¦ÂR-I, ALK-5) (IC50 values are 59, 400 and 1400 nM for TGR-¦Â RI, TGF-¦Â RII and MLK-7K respectively). Inhibits TGF-¦Â-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89 nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.
LY364947

Synonyms: CAS NO: 396129-53-6Molecular Formula: C₁₇H₁₂N₄Molecular Weight: 272.3Purity: 98% minSolubility: In DMSOStorage: −20°C

web site: www.medchemexpress.com

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18524947