LY2228820 is a novel and potent p38MAPK inhibitor: in vitro kinase enzyme activity showed that the IC50 for p38¦ÁMAPK and p38¦ÂMAPK were 7 nM and 3 nM, respectively, while that for p38¦ÄMAPK, p38¦ÃMAPK and a panel of 172 additional kinases was more than 20 µM. Phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, was significantly inhibited by LY in both MM cell lines and LT-BMSCs.

June 21, 2017

prudect name : LY2228820 is a novel and potent p38MAPK inhibitor: in vitro kinase enzyme activity showed that the IC50 for p38¦ÁMAPK and p38¦ÂMAPK were 7 nM and 3 nM, respectively, while that for p38¦ÄMAPK, p38¦ÃMAPK and a panel of 172 additional kinases was more than 20 µM. Phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, was significantly inhibited by LY in both MM cell lines and LT-BMSCs.
LY2228820

Synonyms: CAS NO: 862507-23-1Molecular Formula: C₂₄H₂₉FN₆.₂CH₄O₃SMolecular Weight: 612.74Purity: 98% minSolubility: In DMSOStorage: −20°C

ACY 1215 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18523223