L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 ¦ÌM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. L189 will not only provide insights into the cellular function of these enzymes but also serve as lead compounds for the development of anticancer agents.

June 21, 2017

prudect name : L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 ¦ÌM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. L189 will not only provide insights into the cellular function of these enzymes but also serve as lead compounds for the development of anticancer agents.
L189

Synonyms: CAS NO: 64232-83-3Molecular Formula: C₁₁H₁₀N₄OSMolecular Weight: 246.29Purity: 98% minSolubility: In DMSOStorage: -20°C

BMS-200475 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18523806