Lysophosphatidic acid (LPA) exerts a variety of biological responses through specific receptors: three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly known as EDG-2, EDG-4, and EDG-7, respectively). Ki16425 is a LPA receptor inhibitor with selectivity for LPA1 (Ki = 0.34µM)and LPA3(Ki = 0.93µM)vs. LPA2(Ki = 6.5µM). Ki16425 also inhibited LPA-induced longterm responses, including DNA synthesis and cell migration.

June 21, 2017

prudect name : Lysophosphatidic acid (LPA) exerts a variety of biological responses through specific receptors: three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly known as EDG-2, EDG-4, and EDG-7, respectively).
Ki16425 is a LPA receptor inhibitor with selectivity for LPA1 (Ki = 0.34µM)and LPA3(Ki = 0.93µM)vs. LPA2(Ki = 6.5µM). Ki16425 also inhibited LPA-induced longterm responses, including DNA synthesis and cell migration.
Ki16425

Synonyms: Ki-16425CAS NO: 355025-24-0Molecular Formula: C₂₃H₂₃ClN₂O₅SMolecular Weight: 474.96Purity: 98% minSolubility: In DMSOStorage: −20°C

AFQ 056 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18521390