JNJ-38877605 is an orally bioavailable, highly specific MET inhibitor (selective over other 229 kinases tested). This agent inhibits c-MET and Phospho-MET with IC50 at 4 nmol/L and 50 nmol/L, respectively. In addition, JNJ-38877605 induces regression of U87-MG xenografts in vivo.

June 21, 2017

prudect name : JNJ-38877605 is an orally bioavailable, highly specific MET inhibitor (selective over other 229 kinases tested). This agent inhibits c-MET and Phospho-MET with IC50 at 4 nmol/L and 50 nmol/L, respectively. In addition, JNJ-38877605 induces regression of U87-MG xenografts in vivo.
JNJ 38877605

Synonyms: CAS NO: 943540-75-8Molecular Formula: C₁₉H₁₃F₂N₇Molecular Weight: 377.35Purity: 98% minSolubility: In DMSOStorage: −20°C

MK 8931 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18521012