IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/¦Â-catenin in general and displays no effect against Wnt-stimulated cellular responses.IWP-2 is useful in both regenerative medicine and anticancer efforts. IWP-2 inactivates Porcn, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. IWP-2 blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and ¦Â-catenin accumulation.

June 21, 2017

prudect name : IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/¦Â-catenin in general and displays no effect against Wnt-stimulated cellular responses.IWP-2 is useful in both regenerative medicine and anticancer efforts. IWP-2 inactivates Porcn, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. IWP-2 blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and ¦Â-catenin accumulation.
IWP-2

Synonyms: CAS NO: 686770-61-6Molecular Formula: C₂₂H₁₈N₄O₂S₃Molecular Weight: 466.6Purity: 98% minSolubility: In DMSOStorage: -20°C

GDC 0973 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18519826