INCB 024360 is a potent and novel indoleamine-2,3 dioxygenase (IDO)inhibitor with an IC50 value <100 nM. IC50 Value: <100 nM [1] Target: Indoleamine-2,3-dioxygenase IDO is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells (also used as an immune subversion strategy by many tumors). Interferon-gamma has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase.

June 21, 2017

prudect name : INCB 024360 is a potent and novel indoleamine-2,3 dioxygenase (IDO)inhibitor with an IC50 value <100 nM. IC50 Value: <100 nM [1] Target: Indoleamine-2,3-dioxygenase IDO is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells (also used as an immune subversion strategy by many tumors). Interferon-gamma has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase.
INCB024360

Synonyms: CAS NO: 1204669-58-8Molecular Formula: C₁₁H₁₃BrFN₇O₄SMolecular Weight: 438.23Purity: 98% minSolubility: DMSOStorage: -20¡æ

Seliciclib References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18520135