ICG-001 is a selective Wnt/¦Â-catenin signalling inhibitor with an IC50 of 3¦ÌM. After selectively binding of ICG-001 to the NH2 terminus of cyclic AMP response element binding protein (CREB), ICG-001 prevented beta-catenin/TCF signaling. ICG-001 elevated the activities of caspase in colon carcinoma cell lines, but not normal cells via down regulation of survivin. It is exhibited that ICG-001 rescues defects in neuronal differentiation and reverse pulmonary fibrosis. ICG-001 also suppressed the interaction between CREB and ¦Ã-catenin.

June 21, 2017

prudect name : ICG-001 is a selective Wnt/¦Â-catenin signalling inhibitor with an IC50 of 3¦ÌM. After selectively binding of ICG-001 to the NH2 terminus of cyclic AMP response element binding protein (CREB), ICG-001 prevented beta-catenin/TCF signaling. ICG-001 elevated the activities of caspase in colon carcinoma cell lines, but not normal cells via down regulation of survivin. It is exhibited that ICG-001 rescues defects in neuronal differentiation and reverse pulmonary fibrosis. ICG-001 also suppressed the interaction between CREB and ¦Ã-catenin.
ICG-001

Synonyms: BCP000786CAS NO: 780757-88-2Molecular Formula: C33H32N4O4Molecular Weight: 548.63Purity: 98% minSolubility: In DMSOStorage: −20°C


CP 690550 citrate References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18519927