Genz-123346 is a glucosylceramide synthase inhibitor with potential anticancer activity. Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz-123346 and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, gP-170). In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 was primarily due to the effects on P-gp function.

June 21, 2017

prudect name : Genz-123346 is a glucosylceramide synthase inhibitor with potential anticancer
activity. Exposure of cells to Genz-123346 and to other GCS inhibitors at non-toxic concentrations can enhance the killing of tumor cells by cytotoxic anti-cancer agents. Genz-123346 and a few other GCS inhibitors are substrates for multi-drug resistance efflux pumps such as P-gp (ABCB1, gP-170). In cell lines selected to over-express P-gp or which endogenously express P-gp, chemosensitization by Genz-123346 was primarily due to the effects on P-gp function.
Genz-123346

Synonyms: CAS NO: 491833-30-8Molecular Formula: C₂₄H₃₈N₂O₄Molecular Weight: 418.57Purity: 98% minSolubility: in DMSOStorage: -20oC

RGFP-966 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18517028