Fingolimod (FTY720) is a potent sphingosine-1-phosphate (S1P) receptors agonist with IC50 of 0.137, 10.98 nM for (S)- and (R)- FTY720-phosphate, respectively and reverses the effects of BCR-ABL kinase. It is a novel immunomodulating agent and can sequester lymphocytes in lymph nodes, preventing them from moving to the central nervous system for auto-immune responses in multiple sclerosis and was originally proposed as a anti-rejection medication indicated post-transplantation.

June 21, 2017

prudect name : Fingolimod (FTY720) is a potent sphingosine-1-phosphate (S1P) receptors agonist with IC50 of 0.137, 10.98 nM for (S)- and (R)- FTY720-phosphate, respectively and reverses the effects of BCR-ABL kinase. It is a novel immunomodulating agent and can sequester lymphocytes in lymph nodes, preventing them from moving to the central nervous system for auto-immune responses in multiple sclerosis and was originally proposed as a anti-rejection medication indicated post-transplantation.
Fingolimod hydrochloride

Synonyms: CAS NO: 162359-56-0Molecular Formula: C₁₉H₃₃NO₂.HClMolecular Weight: 343.93Purity: 98% minSolubility: In DMSOStorage: −20°C 2 years

LBH589 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18515009