Epothilone B (EPO906) is a new kind of cancer agents and microtubule function inhibitor with an IC50 of 3.5 nM. Epothilone B (EPO906) inhibits microtubule function. Microtubules are essential to cell division, and epothilones therefore stop cells from properly dividing. Epothilone B (EPO906) possesses the same biological effects as paclitaxel both in vitro and in cultured cells. epothilone B suppressed microtubule dynamics in a concentration-dependent manner coincident with mitotic block. At 0.2 nm epothilone B, dynamics were not significantly altered. At 2 nm epothilone B (EPO906) (IC33), the mean growth and shortening rates were decreased by 38 and 27%, respectively. Dynamicity was decreased by 47%. At the IC50, 80% of the cells had nearly complete stabilization of microtubule dynamics, and no anaphase or telophase figures were observed.

June 21, 2017

prudect name : Epothilone B (EPO906) is a new kind of cancer agents and microtubule function inhibitor with an IC50 of 3.5 nM. Epothilone B (EPO906) inhibits microtubule function. Microtubules are essential to cell division, and epothilones therefore stop cells from properly dividing. Epothilone B (EPO906) possesses the same biological effects as paclitaxel both in vitro and in cultured cells. epothilone B suppressed microtubule dynamics in a concentration-dependent manner coincident with mitotic block. At 0.2 nm epothilone B, dynamics were not significantly altered. At 2 nm epothilone B (EPO906) (IC33), the mean growth and shortening rates were decreased by 38 and 27%, respectively. Dynamicity was decreased by 47%. At the IC50, 80% of the cells had nearly complete stabilization of microtubule dynamics, and no anaphase or telophase figures were observed.
Epothilone B

Synonyms: EPO906 Patupilone CAS NO: 152044-54-7Molecular Formula: C₂₇H₄₁NO₆SMolecular Weight: 507.68Purity: 98% minSolubility: In DMSOStorage: −20°C 2 years

PF04691502 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18512796