Enzastaurin induced marked dose-dependent growth inhibition in all MM cell lines investigated including MM.1S, MM.1R, RPMI 8226 (RPMI), RPMI-Dox40 (Dox40), NCI-H929, KMS-11, OPM-2, and U266.IC50 ranged from 0.6 to 1.6 ¦ÌM. Enzastaurin has a direct effect on human tumor cells, inducing apoptosis and suppressing the proliferation of cultured tumor cells. Enzastaurin treatment also suppresses the phosphorylation of GSK3ßser9, ribosomal protein S6S240/244, and AKTThr308.

June 21, 2017

prudect name : Enzastaurin induced marked dose-dependent growth inhibition in all MM cell lines investigated including MM.1S, MM.1R, RPMI 8226 (RPMI), RPMI-Dox40 (Dox40), NCI-H929, KMS-11, OPM-2, and U266.IC50 ranged from 0.6 to 1.6 ¦ÌM. Enzastaurin has a direct effect on human tumor cells, inducing apoptosis and suppressing the proliferation of cultured tumor cells. Enzastaurin treatment also suppresses the phosphorylation of GSK3ßser9, ribosomal protein S6S240/244, and AKTThr308.
Enzastaurin (LY317615)

Synonyms: LY 317615CAS NO: 170364-57-5Molecular Formula: C₃₂H₂₉N₅O₂Molecular Weight: 515.60Purity: 98% minSolubility: In DMSOStorage: −20°C

PSI 7977 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18513134