EPZ015666 shows potent cellular activity that blocks symmetric dimethylation of SmD3 and inhibit proliferation of MCL cell lines (Z-138, Granta-519, Maver-1, Mino, and Jeko-1) with IC50 of 96-904 nM.EPZ015666 is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs.

June 21, 2017

prudect name : EPZ015666 shows potent cellular activity that blocks symmetric dimethylation of SmD3 and inhibit proliferation of MCL cell lines (Z-138, Granta-519, Maver-1, Mino, and Jeko-1) with IC50 of 96-904 nM.EPZ015666 is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs.
EPZ015666

Synonyms: CAS NO: 1616391-65-1Molecular Formula: C20H25N5O3Molecular Weight: 383.44Purity: 98% minSolubility: In DMSOStorage: −20°C 2 years


BMS354825 References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/18513531