EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes. Following DOT1L inhibition, EPZ004777 selectively inhibits proliferation of MLL-Rearranged cell lines and MLL-AF9-transformed murine hematopoietic cells. In addition, EPZ004777 also induces differentiation and apoptosis in MLL-rearranged cells.

June 21, 2017

prudect name : EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes. Following DOT1L inhibition, EPZ004777 selectively inhibits proliferation of MLL-Rearranged cell lines and MLL-AF9-transformed murine hematopoietic cells. In addition, EPZ004777 also induces differentiation and apoptosis in MLL-rearranged cells.
EPZ004777;EPZ 004777;EPZ-004777

Synonyms: CAS NO: 1338466-77-5Molecular Formula: C₂₈H₄₁N₇O₄Molecular Weight: 539.67Purity: 98% minSolubility: in DMSOStorage: -20oC

CUDC 907 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18514479