Adriamycin (Doxorubicin) is a topoisomerase II inhibitor with IC50 of 1 and 2 ¦ÌM for the inhibition of MCF-7 and MDA-MB231, respectively. Adriamycin (Doxorubicin) is an anthracycline antibiotic and is used in cancer chemotherapy. Adriamycin (Doxorubicin) inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. Doxorubicin stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.

June 21, 2017

prudect name : Adriamycin (Doxorubicin) is a topoisomerase II inhibitor with IC50 of 1 and 2 ¦ÌM for the inhibition of MCF-7 and MDA-MB231, respectively. Adriamycin (Doxorubicin) is an anthracycline antibiotic and is used in cancer chemotherapy. Adriamycin (Doxorubicin) inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. Doxorubicin stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.
Doxorubicin hydrochloride

Synonyms: AdriamycinCAS NO: 25316-40-9Molecular Formula: C27H29NO11.HClMolecular Weight: 579.99Purity: 98% minSolubility: In DMSOStorage: −20°C 2 years


DX 8951f References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18511206