Dofetilide is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug.Dofetilide blocks HERG currents in excised macro patches of Xenopus oocytes. Dofetilide (1 ¦ÌM) reduces the amplitude of IKr to 61% of control currents in guinea pig cardiomyocytes, as measured by 200-ms test pulses and analysis of the deactivating tail currents of IKr. Dofetilide increases apico-basal disparity of repolarization, due to a more marked increase of ERPs in the apex than in the base in the intact canine heart.

June 21, 2017

prudect name : Dofetilide is a selective potassium channel ((hERG)) blocker, used as a Class III antiarrhythmic drug.Dofetilide blocks HERG currents in excised macro patches of Xenopus oocytes. Dofetilide (1 ¦ÌM) reduces the amplitude of IKr to 61% of control currents in guinea pig cardiomyocytes, as measured by 200-ms test pulses and analysis of the deactivating tail currents of IKr. Dofetilide increases apico-basal disparity of repolarization, due to a more marked increase of ERPs in the apex than in the base in the intact canine heart.
Dofetilide

Synonyms: CAS NO: 115256-11-6Molecular Formula: C₁₉H₂₇N₃O₅S₂Molecular Weight: 441.56Purity: Solubility: DMSOStorage: -20°C 2 years

VTX-2337 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18510070