Crenolanib (CP-868569) is a highly selective and potent PDGFR-¦Á inhibitor with IC50 of 0.9 and 1.8 nM against PDGFR¦Á and PDGFR¦Â, respectively. In addition,Crenolanib (CP-868569) inhibits the activity of PDGFR¦Á D842V kinase with an IC50 of 1 nM.Besides, Crenolanib (CP-868569) prevented the phosphorylation of wild type PDGFR¦Á at an IC50 of 10 nM. Imatinib was ineffective in blocking PDGFR¦Á (D842V) phosphorylation (IC50 > 1000 nM). Crenolanib (CP-868569) possesses potential antineoplastic activity. PDGFR inhibitor Crenolanib (CP-868569) binds to and prevents the activity of PDGFR, which may lead to the suppression of PDGFR-related signal transduction pathways, and so the inhibition of tumor angiogenesis and tumor cell proliferation.

June 21, 2017

prudect name : Crenolanib (CP-868569) is a highly selective and potent PDGFR-¦Á inhibitor with IC50 of 0.9 and 1.8 nM against PDGFR¦Á and PDGFR¦Â, respectively. In addition,Crenolanib (CP-868569) inhibits the activity of PDGFR¦Á D842V kinase with an IC50 of 1 nM.Besides, Crenolanib (CP-868569) prevented the phosphorylation of wild type PDGFR¦Á at an IC50 of 10 nM. Imatinib was ineffective in blocking PDGFR¦Á (D842V) phosphorylation (IC50 > 1000 nM). Crenolanib (CP-868569) possesses potential antineoplastic activity. PDGFR inhibitor Crenolanib (CP-868569) binds to and prevents the activity of PDGFR, which may lead to the suppression of PDGFR-related signal transduction pathways, and so the inhibition of tumor angiogenesis and tumor cell proliferation.
Crenolanib (CP-868569)

Synonyms: Crenolanib (CP-868569)CAS NO: 670220-88-9Molecular Formula: C₂₆H₂₉N₅O₂Molecular Weight: 443.54Purity: 98% minSolubility: In DMSOStorage: -20°C

CX 5461 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1850578