Cediranib suppresses PDGF-AA with an IC50 of 0.04 ¦ÌM in MG63 cell lines. Cediranib has been shown to block Flt-1-associated kinase with an IC50 of 5 nM and VEGF-C and VEGF-D receptor Flt-4 with an IC50 of less than 3 nM. In addition, the IC50 values for inhibition of c-Kit and PDGFR-¦Â tyrosine kinase are 2 and 5 nM respectively. Furthermore, no inhibition of enzyme activity is observed when 10 ¦ÌM Cediranib is assayed with 100 ¦ÌM ATP against AMPK, Chk1 Akt/PKB and others. Micromolar concentrations of Cediranib are needed to prevent tumor cell proliferation in vitro.

June 21, 2017

prudect name : Cediranib suppresses PDGF-AA with an IC50 of 0.04 ¦ÌM in MG63 cell lines. Cediranib has been shown to block Flt-1-associated kinase with an IC50 of 5 nM and VEGF-C and VEGF-D receptor Flt-4 with an IC50 of less than 3 nM. In addition, the IC50 values for inhibition of c-Kit and PDGFR-¦Â tyrosine kinase are 2 and 5 nM respectively. Furthermore, no inhibition of enzyme activity is observed when 10 ¦ÌM Cediranib is assayed with 100 ¦ÌM ATP against AMPK, Chk1 Akt/PKB and others. Micromolar concentrations of Cediranib are needed to prevent tumor cell proliferation in vitro.
Cediranib (AZD2171)

Synonyms: Cediranib (AZD2171)CAS NO: 288383-20-0Molecular Formula: C₂₄H₂₅CLFN₅O₃Molecular Weight: 485.94Purity: 98% minSolubility: In DMSOStorage: −20°C 2 years

Basimglurant References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18509244