Canagliflozin is a novel C-glucoside with thiophene ring. Canagliflozin inhibits Na+-dependent 14C-AMG uptake in a concentration-dependent fashion. Canagliflozin inhibits 14C-AMG uptake in CHO-hSGLT1 and mSGLT1 cells with IC50 of 0.7 ¦ÌM and >1 ¦ÌM, respectively. Canagliflozin inhibits the facilitative (non-Na+-linked) GLUT-mediated 2H-2-DG uptake in L6 myoblasts by less than 50%. In sham-injected oocytes, Canagliflozin (10 µM) or phlorizin (3 mM) alone in the presence of 50 µM DNJ does not affect currents. In SGLT3-injected oocytes, DMSO and Canagliflozin 10 µM inhibits DNJ-induced currents by 15.6% and 23.4%, respectively.

June 21, 2017

prudect name : Canagliflozin is a novel C-glucoside with thiophene ring. Canagliflozin inhibits Na+-dependent 14C-AMG uptake in a concentration-dependent fashion. Canagliflozin inhibits 14C-AMG uptake in CHO-hSGLT1 and mSGLT1 cells with IC50 of 0.7 ¦ÌM and >1 ¦ÌM, respectively. Canagliflozin inhibits the facilitative (non-Na+-linked) GLUT-mediated 2H-2-DG uptake in L6 myoblasts by less than 50%. In sham-injected oocytes, Canagliflozin (10 µM) or phlorizin (3 mM) alone in the presence of 50 µM DNJ does not affect currents. In SGLT3-injected oocytes, DMSO and Canagliflozin 10 µM inhibits DNJ-induced currents by 15.6% and 23.4%, respectively.
Canagliflozin

Synonyms: CAS NO: 842133-18-0Molecular Formula: C₂₄H₂₅FO₅SMolecular Weight: 444.52Purity: 98% minSolubility: In DMSOStorage: −20°C

AP 24534 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18508628