CTEP is a research drug developed by Hoffmann-La Roche that acts as a selective allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5, binding with nanomolar affinity and over 1000x selectivity over all other receptor targets tested. In animal studies it was found to have a high oral bioavailability and a long duration of action, lasting 18 hours after a single dose, giving it considerably improved properties over older mGluR5 antagonists such as MPEP and fenobam.

June 21, 2017

prudect name : CTEP is a research drug developed by Hoffmann-La Roche that acts as a selective allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5, binding with nanomolar affinity and over 1000x selectivity over all other receptor targets tested. In animal studies it was found to have a high oral bioavailability and a long duration of action, lasting 18 hours after a single dose, giving it considerably improved properties over older mGluR5 antagonists such as MPEP and fenobam.
CTEP

Synonyms: CAS NO: Molecular Formula: C₁₉H₁₃ClF₃N₃OMolecular Weight: 391.774 Purity: 98% minSolubility: In DMSOStorage: −20°C

PF-2545920 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18493620