Omecamtiv mecarbil (CK-1827452) is a selective sarcomere-directed cardiac myosin activator with an E50 of 0.6 ¦ÌM. Omecamtiv mecarbil (CK-1827452) represents a novel myosin activator that acts independently of Ca2+, with an advantage compared with inotropic agents that elevate cAMP, enhance Ca2+ fluxes and have the potential to induce arrhythmias. Omecamtiv mecarbil (CK-1827452) accelerates productive phosphate release. Omecamtiv mecarbil (CK-1827452) improves systolic function by increasing the systolic ejection duration/stroke volume, without consuming more ATP energy, oxygen or altering intracellular calcium levels causing an overall improvement in cardiac efficiency.

June 21, 2017

prudect name : Omecamtiv mecarbil (CK-1827452) is a selective sarcomere-directed cardiac myosin activator with an E50 of 0.6 ¦ÌM. Omecamtiv mecarbil (CK-1827452) represents a novel myosin activator that acts independently of Ca2+, with an advantage compared with inotropic agents that elevate cAMP, enhance Ca2+ fluxes and have the potential to induce arrhythmias. Omecamtiv mecarbil (CK-1827452) accelerates productive phosphate release. Omecamtiv mecarbil (CK-1827452) improves systolic function by increasing the systolic ejection duration/stroke volume, without consuming more ATP energy, oxygen or altering intracellular calcium levels causing an overall improvement in cardiac efficiency.
CK1827452

Synonyms: Omecamtiv mecarbilCAS NO: 873697-71-3Molecular Formula: C₂₀H₂₄FN₅O₃Molecular Weight: 401.43Purity: 98% minSolubility: In DMSOStorage: -20°C

LDN 193189 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18505774