CHIR-99021(CT99021) is a glycogen synthase kinase 3¦Â (GSK3¦Â) inhibitor that has antiproliferative activity in vitro and in vivo. [1] CHIR-99021 inhibits GSK-3 with IC50 at 7 nM. In a series of carcinoma cell lines, the IC50 of CHIR99021 for proliferation is about 10¦ÌM. [1] CHIR-99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) with 350-fold selectivity toward GSK-3¦Â compared to CDKs

June 21, 2017

prudect name : CHIR-99021(CT99021) is a glycogen synthase kinase 3¦Â (GSK3¦Â) inhibitor that has antiproliferative activity in vitro and in vivo. [1] CHIR-99021 inhibits GSK-3 with IC50 at 7 nM. In a series of carcinoma cell lines, the IC50 of CHIR99021 for proliferation is about 10¦ÌM. [1] CHIR-99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) with 350-fold selectivity toward GSK-3¦Â compared to CDKs
CHIR-99021 (CT99021)

Synonyms: CHIR-99021 (CT99021)CAS NO: 252917-06-9Molecular Formula: C₂₂H₁₈Cl₂N₈Molecular Weight: 465.34Purity: 98% minSolubility: In DMSOStorage: −20°C

VX 809 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18508833