RAF265 (CHIR-265) is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 ¦ÌM. RAF is a key component of the RAS/RAF/MEK/ERK signal-transduction pathway, which controls cell proliferation, differentiation, and apoptosis in mammalian cells. Raf265 also has anti-angiogenic activity through inhibition of vascular endothelial growth factor receptor 2 (VEGFR-2).

June 21, 2017

prudect name : RAF265 (CHIR-265) is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 ¦ÌM. RAF is a key component of the RAS/RAF/MEK/ERK signal-transduction pathway, which controls cell proliferation, differentiation, and apoptosis in mammalian cells. Raf265 also has anti-angiogenic activity through inhibition of vascular endothelial growth factor receptor 2 (VEGFR-2).
CHIR-265 or RAF265

Synonyms: CHIR-265 or RAF265 CAS NO: 927880-90-8Molecular Formula: C₂₄H₁₆F₆N₆OMolecular Weight: 518.41Purity: 98% minSolubility: In DMSOStorage: −20°C

Mdivi 1 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18505992