CHIR-124 is a novel and potent chk1 inhibitor with an IC50 of 0.3 nM. Chk1 kinase is a critical regulator of both the S and G2/M phase cell cycle checkpoints in response to DNA damage. CHIR-124 has been shown that inhibitors of chk1 can selectively sensitize tumor cells with mutant p53 to genotoxic agents.

June 21, 2017

prudect name : CHIR-124 is a novel and potent chk1 inhibitor with an IC50 of 0.3 nM. Chk1 kinase is a critical regulator of both the S and G2/M phase cell cycle checkpoints in response to DNA damage. CHIR-124 has been shown that inhibitors of chk1 can selectively sensitize tumor cells with mutant p53 to genotoxic agents.
CHIR-124.

Synonyms: CAS NO: 405168-58-3Molecular Formula: C₂₃H₂₂ClN₅OMolecular Weight: 419.91Purity: 98% minSolubility: In DMSOStorage: -20°C

BMS-512148 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18508572