CAY10505 is a potent PI3K¦Ã inhibitor with an IC50 of 30 nM. Phosphoinositide 3-kinase ¦Ã (PI3K¦Ã) is expressed primarily in hematopoietic cells and plays several important roles in immunity. CAY10505 also prevents other ¦Á, ¦Â, and ¦Ä isoforms with IC50 of 0.94, 20, and 20 ¦ÌM, respectively. CAY10505 significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). CAY10505 also suppress the phosphorylation of the PI3K substrate PKB/Akt in murine macrophages (IC50 = 228 nM). Oral administration of CAY10505 decreases neutrophil recruitment in mice to an extent that is comparable to that observed in PI3K¦Ã-deficient mice.

June 21, 2017

prudect name : CAY10505 is a potent PI3K¦Ã inhibitor with an IC50 of 30 nM. Phosphoinositide 3-kinase ¦Ã (PI3K¦Ã) is expressed primarily in hematopoietic cells and plays several important roles in immunity. CAY10505 also prevents other ¦Á, ¦Â, and ¦Ä isoforms with IC50 of 0.94, 20, and 20 ¦ÌM, respectively. CAY10505 significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). CAY10505 also suppress the phosphorylation of the PI3K substrate PKB/Akt in murine macrophages (IC50 = 228 nM). Oral administration of CAY10505 decreases neutrophil recruitment in mice to an extent that is comparable to that observed in PI3K¦Ã-deficient mice.
CAY10505

Synonyms: CAS NO: 1218777-13-9Molecular Formula: C₁₄H₈FNO₃SMolecular Weight: 289.28 Purity: 98% minSolubility: In DMSOStorage: −20°C

XL184 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18505770