Belinostat (PXD101) is a novel hydroxamate-type inhibitor of histone deacetylase (HDAC) activity. Belinostat inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM. PXD101 is cytotoxic in vitro in a number of tumor cell lines with IC50s in the range of 0.2-3.4 uM as determined by a clonogenic assay and induces apoptosis.

June 21, 2017

prudect name : Belinostat (PXD101) is a novel hydroxamate-type inhibitor of histone deacetylase (HDAC) activity. Belinostat inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM. PXD101 is cytotoxic in vitro in a number of tumor cell lines with IC50s in the range of 0.2-3.4 uM as determined by a clonogenic assay and induces apoptosis.
Belinostat (PXD101)

Synonyms: PX105684CAS NO: 414864-00-9Molecular Formula: C₁₅H₁₄N₂O₄SMolecular Weight: 318.35Purity: 98% minSolubility: In DMSOStorage: −20°C

1454846-35-5 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18502944