BMS 777607 is a Small-Molecule Met Kinase Inhibitor with an IC50 of < 0.1 ¦ÌM. Its treatment had little effect on tumor cell growth but inhibited cell scattering activated by exogenous HGF, with almost complete inhibition at 0.5 ¦Ìmol/L in PC-3 and DU145 cells. This agent also suppressed HGF-stimulated cell migration and invasion in a dose-dependent fashion (IC50 < 0.1 ¦Ìmol/L) in both cell lines. Mechanistically, nanomolar doses of BMS 777607 potently blocked HGF-stimulated c-Met autophosphorylation and downstream activation of Akt and extracellular signal-regulated kinase. In addition, both wortmannin and U0126, but not dasatinib, attenuated cell scattering and migration induced by HGF, suggesting the involvement of the phosphoinositide 3-kinase and mitogen-activated protein kinase pathways, but not of Src or focal adhesion kinase, in HGF-mediated motogenic effects.

June 21, 2017

prudect name : BMS 777607 is a Small-Molecule Met Kinase Inhibitor with an IC50 of < 0.1 ¦ÌM. Its treatment had little effect on tumor cell growth but inhibited cell scattering activated by exogenous HGF, with almost complete inhibition at 0.5 ¦Ìmol/L in PC-3 and DU145 cells. This agent also suppressed HGF-stimulated cell migration and invasion in a dose-dependent fashion (IC50 < 0.1 ¦Ìmol/L) in both cell lines. Mechanistically, nanomolar doses of BMS 777607 potently blocked HGF-stimulated c-Met autophosphorylation and downstream activation of Akt and extracellular signal-regulated kinase. In addition, both wortmannin and U0126, but not dasatinib, attenuated cell scattering and migration induced by HGF, suggesting the involvement of the phosphoinositide 3-kinase and mitogen-activated protein kinase pathways, but not of Src or focal adhesion kinase, in HGF-mediated motogenic effects.
BMS777607

Synonyms: CAS NO: 1025720-94-8Molecular Formula: C₂₅H₁₉ClF₂N₄O₄Molecular Weight: 512.89Purity: 99%Solubility: In DMSOStorage: −20°C

Silmitasertib References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18505119