BIX 02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM. It inhibited catalytic function of purified, MEK5 enzyme. The MEK5 inhibitors blocked phosphorylation of ERK5, without affecting phosphorylation of ERK1/2 in sorbitol-stimulated HeLa cells. The compounds also inhibited transcriptional activation of MEF2C, a downstream substrate of the MEK5/ERK5 signaling cascade, in a cellular trans-reporter assay system.

June 21, 2017

prudect name : BIX 02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM. It inhibited catalytic function of purified, MEK5 enzyme. The MEK5 inhibitors blocked phosphorylation of ERK5, without affecting phosphorylation of ERK1/2 in sorbitol-stimulated HeLa cells. The compounds also inhibited transcriptional activation of MEF2C, a downstream substrate of the MEK5/ERK5 signaling cascade, in a cellular trans-reporter assay system.
BIX 02189

Synonyms: CAS NO: 1094614-85-3Molecular Formula: C₂₇H₂₈N₄O₂Molecular Weight: 440.54Purity: 98% minSolubility: In DMSOStorage: −20°C

Telcagepant References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18504447