BIX02188 is a MEK5-selective inhibitor with an IC50 of 0.8 ¡À 1.0 ¦ÌM. It completely reversed the inhibitory effects of flow. [1] The physiological roles of ERK5 in neuronal cells have not been clarified. One reason was the lack of a selective ERK5 pharmacological inhibitor until the novel selective MEK5/ERK5 inhibitors BIX02188 and BIX02189.

June 21, 2017

prudect name : BIX02188 is a MEK5-selective inhibitor with an IC50 of 0.8 ¡À 1.0 ¦ÌM. It completely reversed the inhibitory effects of flow. [1] The physiological roles of ERK5 in neuronal cells have not been clarified. One reason was the lack of a selective ERK5 pharmacological inhibitor until the novel selective MEK5/ERK5 inhibitors BIX02188 and BIX02189.
BIX 02188

Synonyms: CAS NO: 1094614-84-2Molecular Formula: C₂₅H₂₄N₄O₂Molecular Weight: 412.48Purity: 98% minSolubility: In DMSOStorage: −20°C

GS-5806 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18504547