Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 – 9 ¦ÌM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 ¦ÌM).

June 21, 2017

prudect name : Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 – 9 ¦ÌM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 ¦ÌM).
Apoptosis Activator 2

Synonyms: CAS NO: 79183-19-0Molecular Formula: C₁₅H₉Cl₂NO₂Molecular Weight: 306.14Purity: 98% minSolubility: In DMSOStorage: −20°C

192185-72-1 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18500447