MP-470 is a multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Met, c-Kit, PDGFRalpha, Flt3, and c-Ret and with an IC50 of median 5 ¦ÌM. MP-470 reduced c-Met phosphorylation and enhanced radiation-induced cell kill by 0.4 logs in SF767 cells. Cells pretreated with MP-470 had more ds DNA damage than cells treated with radiation alone. Mechanistically, MP-470 was shown to inhibit dsDNA break repair and increase apoptosis.

June 21, 2017

prudect name : MP-470 is a multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Met, c-Kit, PDGFRalpha, Flt3, and c-Ret and with an IC50 of median 5 ¦ÌM. MP-470 reduced c-Met phosphorylation and enhanced radiation-induced cell kill by 0.4 logs in SF767 cells. Cells pretreated with MP-470 had more ds DNA damage than cells treated with radiation alone. Mechanistically, MP-470 was shown to inhibit dsDNA break repair and increase apoptosis.
Amuvatinib MP-470

Synonyms: Amuvatinib MP-470CAS NO: 850879-09-3Molecular Formula: C₂₃H₂₁N₅O₃SMolecular Weight: 447.51Purity: 98% minSolubility: In DMSOStorage: −20°C

585543-15-3 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18498521