17-DMAG HCl (Alvespimycin), a watersoluble geldanamycin analog belonging to the class of benzoquinones, is a selective Hsp90 inhibitor. 17-DMAG HCl binds to the N-terminal domain ATP binding site of Hsp90, inhibiting Hsp90 chaperone activity. 17-DMAG HCl demonstrates greater potency and water solubility than other geldanamycin analogs such as 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG HCl and 17-AAG respectively), while demonstrating anti-tumor activity and offering excellent oral bioavailability.

June 21, 2017

prudect name : 17-DMAG HCl (Alvespimycin), a watersoluble geldanamycin analog belonging to the class of benzoquinones, is a selective Hsp90 inhibitor. 17-DMAG HCl binds to the N-terminal domain ATP binding site of Hsp90, inhibiting Hsp90 chaperone activity. 17-DMAG HCl demonstrates greater potency and water solubility than other geldanamycin analogs such as 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG HCl and 17-AAG respectively), while demonstrating anti-tumor activity and offering excellent oral bioavailability.
Alvespimycin

Synonyms: CAS NO: 467214-20-6Molecular Formula: C₃₂H₄₈N₄O₈Molecular Weight: 616.75Purity: 98%Solubility: In DMSOStorage: −20°C 2 years

755038-65-4 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1849784