AZD8835 is a selective, oral inhibitor of PI3K isoforms ¦Á and ¦Ä with the following activity in enzymatic assays: PI3K ¦Á ¨C IC50 = 6nM (equipotent vs wt and E545K / H1047R mutants); PI3K ¦Ä ¨C IC50 = 6nM; PI3K ¦Ã ¨C IC50 = 90nM; PI3K ¦Â ¨C IC50 = 431nM. Inhibition of signalling in cells (pAKT endpoint): PI3K ¦Á ¨C IC50= 57nM; PI3K ¦Ä ¨C IC50= 49nM; PI3K ¦Â ¨C IC50= 3.6¦ÌM; PI3K ¦Ã- IC50= 532nM

June 21, 2017

prudect name : AZD8835 is a selective, oral inhibitor of PI3K isoforms ¦Á and ¦Ä with the following activity in enzymatic assays: PI3K ¦Á ¨C IC50 = 6nM (equipotent vs wt and E545K / H1047R mutants); PI3K ¦Ä ¨C IC50 = 6nM; PI3K ¦Ã ¨C IC50 = 90nM; PI3K ¦Â ¨C IC50 = 431nM. Inhibition of signalling in cells (pAKT endpoint): PI3K ¦Á ¨C IC50= 57nM; PI3K ¦Ä ¨C IC50= 49nM; PI3K ¦Â ¨C IC50= 3.6¦ÌM; PI3K ¦Ã- IC50= 532nM
AZD 8835;AZD8835

Synonyms: CAS NO: 1620576-64-8Molecular Formula: C₂₂H₃₁N₉O₃ Molecular Weight: 469.55 Purity: 98% minSolubility: In DMSOStorage: -20 oC

202138-50-9 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18500808