AZD8186 potently inhibits p-Akt in MDA-MB-468 cells sensitive to PI3K¦Â inhibition and Jeko B cells sensitive to PI3K¦Ä inhibition with IC50 of 3 nM and 4 nM, respectively. AZD8186 shows preferred growth inhibition activity in most PTEN deficient cell lines with GI50 of <1 ¦ÌM.

June 21, 2017

prudect name : AZD8186 potently inhibits p-Akt in MDA-MB-468 cells sensitive to PI3K¦Â inhibition and Jeko B cells sensitive to PI3K¦Ä inhibition with IC50 of 3 nM and 4 nM, respectively. AZD8186 shows preferred growth inhibition activity in most PTEN deficient cell lines with GI50 of <1 ¦ÌM.
AZD 8186;AZD8186

Synonyms: CAS NO: 1627494-13-6Molecular Formula: C₂₄H₂₅F₂N₃O₄Molecular Weight: 457.47Purity: 98% minSolubility: In DMSOStorage: -20 oC

937174-76-0 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18499566