Poly(adenosine diphosphate-ribose) polymerase (PARP) is anenzyme that is involved in a specific kind of DNA repair called base-excision repair, which is used when there is an error in a strand of the DNA.IC50 (¦ÌM):PARP-1= 0.005,PARP-2= 0.001 , PF50=25.8.AZD2281(Olaparib) at 400 mg twice daily is well tolerated and highly active. The toxicity that was seen in BRCA1/BRCA2 carriers was similar to the previously reported toxicity in noncarriers

June 21, 2017

prudect name : Poly(adenosine diphosphate-ribose) polymerase (PARP) is anenzyme that is involved in a specific kind of DNA repair called base-excision repair, which is used when there is an error in a strand of the DNA.IC50 (¦ÌM):PARP-1= 0.005,PARP-2= 0.001 , PF50=25.8.AZD2281(Olaparib) at 400 mg twice daily is well tolerated and highly active. The toxicity that was seen in BRCA1/BRCA2 carriers was similar to the previously reported toxicity in noncarriers
AZD2281 Olaparib

Synonyms: AZD2281,KU-0059436CAS NO: 763113-22-0 937799-91-2Molecular Formula: C₂₄H₂₃FN₄O₃Molecular Weight: 434.46Purity: 99%Solubility: In DMSOStorage: −20°C

1341224-83-6 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18496843