AZD1152-HQPA (Barasertib) is a highly potent and selective Aurora B inhibitor with a Ki of 0.36 nM. AZD1152-HQPA (Barasertib) inhibits Aurora A with a Ki of 1.37 nM. AZD1152 is converted rapidly to the active AZD1152-HQPA (Barasertib) in plasma. AZD1152-HQPA (Barasertib) has a high specificity versus a panel of 50 other kinases. Consistent with inhibition of Aurora B kinase, addition of AZD1152-HQPA (Barasertib) to tumor cells in vitro induces chromosome misalignment, prevents cell division, and consequently reduces cell viability and induces apoptosis.

June 21, 2017

prudect name : AZD1152-HQPA (Barasertib) is a highly potent and selective Aurora B inhibitor with a Ki of 0.36 nM. AZD1152-HQPA (Barasertib) inhibits Aurora A with a Ki of 1.37 nM. AZD1152 is converted rapidly to the active AZD1152-HQPA (Barasertib) in plasma. AZD1152-HQPA (Barasertib) has a high specificity versus a panel of 50 other kinases. Consistent with inhibition of Aurora B kinase, addition of AZD1152-HQPA (Barasertib) to tumor cells in vitro induces chromosome misalignment, prevents cell division, and consequently reduces cell viability and induces apoptosis.
AZD1152-HQPA (Barasertib)

Synonyms: AZD1152-HQPA (Barasertib)CAS NO: 722544-51-6Molecular Formula: C₂₆H₃₀FN₇O₃Molecular Weight: 507.56Purity: 98% minSolubility: In DMSOStorage: -20°C

606143-52-6 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18498744