AS-605240 is a PI3K ¦Ã inhibitor (IC50 at 8 nM), which displays 30-fold selectivity over PI3K¦Ä and PI3K¦Â and 7.5-fold selectivity over PI3K¦Á. This agent is the first examples of selective PI3K ¦Ã inhibitors, and was used to block neutrophil chemotaxis in vitro and in vivo. In passive mouse models for rheumatoid arthritis these compounds minimized progression of joint destruction.

June 21, 2017

prudect name : AS-605240 is a PI3K ¦Ã inhibitor (IC50 at 8 nM), which displays 30-fold selectivity over PI3K¦Ä and PI3K¦Â and 7.5-fold selectivity over PI3K¦Á. This agent is the first examples of selective PI3K ¦Ã inhibitors, and was used to block neutrophil chemotaxis in vitro and in vivo. In passive mouse models for rheumatoid arthritis these compounds minimized progression of joint destruction.
AS-605240

Synonyms: CAS NO: 648450-29-7Molecular Formula: C₁₂H₇N₃O₂SMolecular Weight: 257.27Purity: 98% minSolubility: In DMSOStorage: −20°C

875787-07-8 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18501660