AS-604850 is a selective, ATP-competitive PI3K¦Ã inhibitor with IC50 of 0.25, >20, >20, and 4.5 µM for the human recombinant ¦Ã, ¦Ä, ¦Â, and ¦Á isoforms, respectively. AS-604850 shows no notable activity against a wide array of protein kinases at 1 ¦ÌM. AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.

June 21, 2017

prudect name : AS-604850 is a selective, ATP-competitive PI3K¦Ã inhibitor with IC50 of 0.25, >20, >20, and 4.5 µM for the human recombinant ¦Ã, ¦Ä, ¦Â, and ¦Á isoforms, respectively. AS-604850 shows no notable activity against a wide array of protein kinases at 1 ¦ÌM. AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.
AS-604850

Synonyms: CAS NO: 648449-76-7Molecular Formula: C₁₁H₅F₂NO₄SMolecular Weight: 285.2Purity: 98% minSolubility: In DMSOStorage: −20°C

53003-10-4 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18502753