AS-252424 is a potent and selective PI3k ¦Ã inhibitor with IC50 of 33 and 935 nM for PI3K¦Ã and PI3K¦Á, respectively. Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of Pl at the 3 position to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. AS-252424 inhibits human recombinant PI3K¦Â, and ¦Ä with IC50 values of 20,000, and 20,000 nM, respectively. AS-252424 also prevents C5a-mediated phosphorylation of Akt in RAW 264.7 macrophages with an IC50 of 0.23 µM. AS-252424 inhibited neutrophil recruitment 35% at a dose of 10 mg/kg in a mouse model of peritonitis

June 21, 2017

prudect name : AS-252424 is a potent and selective PI3k ¦Ã inhibitor with IC50 of 33 and 935 nM for PI3K¦Ã and PI3K¦Á, respectively. Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of Pl at the 3 position to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. AS-252424 inhibits human recombinant PI3K¦Â, and ¦Ä with IC50 values of 20,000, and 20,000 nM, respectively. AS-252424 also prevents C5a-mediated phosphorylation of Akt in RAW 264.7 macrophages with an IC50 of 0.23 µM. AS-252424 inhibited neutrophil recruitment 35% at a dose of 10 mg/kg in a mouse model of peritonitis
AS-252424

Synonyms: CAS NO: 900515-16-4Molecular Formula: C₁₄H₈FNO₄SMolecular Weight: 305.28Purity: 98% minSolubility: In DMSOStorage: −20°C

302962-49-8 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18498523