AST-1306 is a novel irreversible epidermal growth factor receptor inhibitor for EGFR and ErbB4 with IC50 of 0.5 and 0.8 nM, respectively. AST-1306 selectively inhibits the tyrosine kinase activities of ErbB2 with an IC50 of 3 nM. AST-1306 also potently prevents the EGFR T790M/L858R double mutant with an IC50 value of 12 nM.

June 21, 2017

prudect name : AST-1306 is a novel irreversible epidermal growth factor receptor inhibitor for EGFR and ErbB4 with IC50 of 0.5 and 0.8 nM, respectively. AST-1306 selectively inhibits the tyrosine kinase activities of ErbB2 with an IC50 of 3 nM. AST-1306 also potently prevents the EGFR T790M/L858R double mutant with an IC50 value of 12 nM.
AST-1306

Synonyms: CAS NO: 1050500-29-2Molecular Formula: C₂₄H₁₈ClFN₄O₂,C₇H₈O₃SMolecular Weight: 621.08Purity: 98% minSolubility: In DMSOStorage: −20°C

128517-07-7 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18500230