ARRY-380 is equipotent against truncated p95-HER2 with an IC50 of 7 nM. [1] However, ARRY-380 suppresses EGFR with an IC50 of 4 ¦ÌM. ARRY-380 is about 500-fold selective for HER2 versus EGFR.ARRY-380 significantly prevents the growth of tumor in multiple HER2-dependent tumor xenograft models and displays additive activity in combination with standard-of-care agents.

June 21, 2017

prudect name : ARRY-380 is equipotent against truncated p95-HER2 with an IC50 of 7 nM. [1] However, ARRY-380 suppresses EGFR with an IC50 of 4 ¦ÌM. ARRY-380 is about 500-fold selective for HER2 versus EGFR.ARRY-380 significantly prevents the growth of tumor in multiple HER2-dependent tumor xenograft models and displays additive activity in combination with standard-of-care agents.
ARRY380

Synonyms: CAS NO: 937265-83-3Molecular Formula: C₂₉H₂₇N₇O₄SMolecular Weight: 569.63Purity: 98% minSolubility: In DMSOStorage: -20°C

864070-44-0 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18499752